Research Associate - Tisch Lab

A global higher education leader in innovative teaching, research and public service, the University of North Carolina at Chapel Hill consistently ranks as one of the nation's top public universities. Known for its beautiful campus, world-class medical care, commitment to the arts and top athletic programs, Carolina is an ideal place to teach, work and learn.

One of the best college towns and best places to live in the United States, Chapel Hill has diverse social, cultural, recreation and professional opportunities that span the campus and community.

University employees can choose from a wide range of professional training opportunities for career growth, skill development and lifelong learning and enjoy exclusive perks for numerous retail, restaurant and performing arts discounts, savings on local child care centers and special rates on select campus events. UNC-Chapel Hill offers full-time employees a comprehensive benefits package, paid leave, and a variety of health, life and retirement plans and additional programs that support a healthy work/life balance.

Our mission is to improve the health and well-being of North Carolinians and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education and research.

Patient care: We promote health and provide superb clinical care while maintaining our strong tradition of reaching underserved populations and reducing health disparities across North Carolina and beyond.

Education: We prepare tomorrow`s healthcare professionals and biomedical researchers from all backgrounds by facilitating learning within innovative and integrated curricula and team-oriented interprofessional education to ensure a highly skilled workforce.

Research: We develop and support a rich array of outstanding health sciences research programs, centers and resources. We provide infrastructure and opportunities for collaboration among disciplines throughout and beyond our university to support outstanding research. We foster programs in the areas of basic, translational, mechanistic and population research.

The position entails defining the biochemical and molecular signaling events mediated by two distinct types of molecules; namely 1) AIM2 and 2) the CD4 and CD8 coreceptor molecules. Studies will be carried out to determine how AIM2 interacts with different biochemical signaling pathways, in particular the PI3K/ AKT pathway. Immune effectors such as T cells and dendritic cells will be examined. For the second set of analyses, work will be carried out to define the biochemical and transcriptional signaling events induced by antibody binding to CD4/CD8 that modulate the pathogenicity of autoreactive T cells. Both sets of analyses will entail measurement of biochemical and transcriptional signaling events via flow cytometry, immunoblot, quantitative PCR, and gene microarrays.

Relevant post-Baccalaureate degree required (or foreign degree equivalent); for candidates demonstrating comparable independent research productivity, will accept a relevant Bachelor's degree (or foreign degree equivalent) and 3 or more years of relevant experience in substitution. May require terminal degree and licensure.

Minimum four years of work experience with the scientific method and experimental design and interpretation is necessary. The position also requires quantitative biological and chemical expertise and experience using flow cytometry, immunoblot, quantitative PCR, and gene microarrays, which could be obtained during the course of study for a PhD and/or during the 4 years of work experience required.

The University is an equal opportunity employer and welcomes all to apply without regard to age, color, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, or sexual orientation. We encourage all qualified applicants to apply, including protected veterans and individuals with disabilities.