Principal Scientist, Medicinal Chemistry

Job Description Summary

Job Description

Internal Job Title: Principal Scientist I

Position Location: Cambridge, MA, onsite #LI-onsite

Job Description

We are seeking a highly talented and motivated synthetic / medicinal chemist to join the Global Discovery Chemistry group at BioMedical Research at our Cambridge, MA site. We are a highly collaborative and global group of curious, unbossed chemists across multiple disciplines where we value your ideas, personal growth, and career aspirations. You will be given opportunities to explore the power of cutting-edge science and technology and be empowered to take smart risks. Using your creativity and tenacity, you will contribute to the discovery, development, and characterization of small molecules to further GDC's mission to discover innovative medicines

Your key responsibilities:

• Contribute at all stages of the drug discovery process, from inception, early project validation, optimization, candidate selection, and through to early development.

• Collaborate with peers and work effectively and efficiently as an important part of a cross-functional team where you will identify key drug discovery issues, propose, and implement creative solutions, execute on innovative medicinal chemistry designs, and guide projects to decision points.

• Propose and explore new research directions, projects, and/or new technologies.

• Act as a source of drug discovery expertise, demonstrate impact beyond your project team, and mentor colleagues.

• Work closely with computational chemistry colleagues and apply modern digital and data technologies to drug discovery.

• Independently design and synthesize compounds based off team or individual hypotheses, utilize novel methodologies and technologies, and conduct multi-step syntheses of small molecules

• Use contemporary medicinal chemistry principles to drive science to key decision points

• Analyze and interpret data, solve synthetic issues, and design follow-up experiments

• Adhere to laboratory safety policies and practices

Essential requirements

• BS or MS degree in organic chemistry with 15+ years of industrial medicinal chemistry experience in design, synthesis, and characterization of organic compounds

• A comprehensive knowledge of modern organic synthetic methods; medicinal chemistry, and digital tools and analysis for medicinal chemistry

• Strong problem solving and outstanding communication skills

• Knowledge and efficient use of IT applications used to support the planning and execution of synthesis experiments, and communication of results

• A strong collaborative approach to drive the effectiveness of a drug discovery team

• Excellence in common purification, analytical techniques, and spectroscopy (NMR, UV, MS)

The salary for this position is expected to range between $103,600 and $192,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days,
holidays and other leaves.

To learn more about the culture, rewards and benefits we offer our people click here.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

Skills Desired